British Air Force Typhoon FGR4s have operated alongside France's air force in a combined operation on an hidden munitions depot in Syria operated by the IS group, according to the British defence ministry.
The site, identified by reconnaissance, was believed to be housing weapons and explosive materials, the announcement noted, and was located in mountainous terrain just above the historic site of Palmyra in the heart of Syria.
"Our fighter planes employed Paveway IV guided bombs to target a series of entry passages providing entry to the site... early reports are that the strike was effective," officials stated.
There was no sign of any civilian impact in the attack on Saturday evening and each participating jet returned safely, the MoD added.
The British jets were assisted by a Voyager tanker plane.
IS - also known as the so-called Islamic State - established extremist governance over significant areas in Syria and Iraq before its territorial defeat in 2019.
"This strike demonstrates British leadership, and commitment to operate in unison with our allies, to eliminate any re-emergence of the terrorist group and their violent and radical beliefs in the region," the British Defence Secretary John Healey stated.
RAF aircraft have carried out surveillance missions over Syrian airspace to "prevent any attempted comeback" of the group subsequent to its routing at the climactic battle in Baghuz in the year 2019, the authorities noted.
"I extend gratitude to the personnel of British forces involved in this mission for their expertise and their bravery," the Defence Secretary added. "They were part of thousands of British personnel on duty over the holidays. This mission, to take out militants who pose a risk to our safety, shows how UK forces are prepared to act, throughout the year, ensuring Britain's security within its borders and influential overseas."
During December, the United States armed forces carried out what it described as a "massive strike" against Daesh sites in Syria, following an attack killed two American soldiers and a civilian linguist in the Palmyra area.
The United Nations estimates Daesh still has an estimated 5,000 to 7,000 fighters in Syria and Iraq.